Journal
MICROCHIMICA ACTA
Volume 185, Issue 2, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-018-2697-6
Keywords
Metal-organic framework; Functional composite; Solidphase microextraction; Magnetic separation; Urine samples; Chromatographic analysis; Sample preparation
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Funding
- Independent Innovation Fund Project of Agricultural Science and Technology of Jiangsu Province [CX (17) 1003]
- Guizhou Provincial Science and Technology Department Joint Fund Project [7076]
- Research Project of Environment Protection Department of Jiangsu Province [2015026]
- Chinese College Students Innovation Project for the R&D of Novel Drugs [J1310032]
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Graphene oxide (GO), nanosized Fe3O4 and zeolite imidazolate framework-8 (ZIF-8) were hybridized as a multifunctional sorbent for use in microextraction. The sorbent was characterized by SEM, TEM, XRD and FTIR. The composite is porous, has a high specific surface (> 600 m(2)center dot g(-1)) and is paramagnetic. The GO sheets are shown to act as carriers for the Fe3O4 nanoparticles and ZIF-8. The composite is a viable material for the preconcentration of atorvastatin and simvastatin from urine prior to their determination by HPLC with PDA detection. The limits of detection are 116 and 387 pg center dot mL(-1), respectively. Recoveries from spiked urine samples range between 84.7 and 95.7%, with relative standard deviation of <= 4.5%. Enrichment factors range from 169 to 191. The method was successfully applied to the determination of atorvastatin in urine. Moreover, this sorbent is regenerable and recyclable for at least seven times without obvious decrease in performance.
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