Journal
MICROBIAL PATHOGENESIS
Volume 123, Issue -, Pages 242-245Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2018.07.021
Keywords
Vibrio parahaemolyticus; TDH; Regulation
Categories
Funding
- National Natural Science Foundation of China [81601809, 31671290, 31471184]
- Natural Science Foundation of Jiangsu Province [BK20160505]
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Vibrio parahaemolyticus is a leading cause of seafood-associated bacterial gastroenteritis. The pathogen produces the thermostable direct hemolysin (TDH), which is the sole cause of the Kanagawa phenomenon (KP), a special beta-type haemolysis in the Wagatsuma agar. TDH also exerts several other biological activities, the major includes lethal toxicity, cytotoxicity, and enterotoxicity. The structure and roles of TDH and the transcriptional regulation of tdh genes, are summarized in this review, which will give a better understanding of the pathogenesis of V. parahaemolyticus.
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