Journal
MICROBIAL PATHOGENESIS
Volume 118, Issue -, Pages 316-321Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2018.03.047
Keywords
TFF2; Helicobacter pylori; High-salt diet; Gastric disease; Mongolian gerbils
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Funding
- Public Welfare Research Fund Project of Liaoning [20170025]
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This study aimed to elucidate the effect of Helicobacter pylori (H. pylori) and high salt diet on Trefoil factor 2 (TFF2) expression level of Mongolian gerbils (MGs) gastric mucosa. The results of H. pylori identification and histopathology showed that H. pylori infected MGs model was built successfully. According to the immunohistochemical staining results, 25% (4/16) of H. pylori infected MGs with high salt diet showed high TFF2 expression, which was significantly lower than H. pylori infection group 61% (11/18)(P = 0.045). The results suggested that High salt diet could down-regulated TFF2 expression level of MGs gastric mucosa induced by H. pylori infection.
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