Journal
MICROBIAL PATHOGENESIS
Volume 116, Issue -, Pages 164-167Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2018.01.025
Keywords
Vibrio parahaemolyticus; H-NS; ScrABC; CpsQ; cpsA-J; c-di-GMP
Categories
Funding
- National Natural Science Foundation of China [81601809]
- Natural Science Foundation of Jiangsu Province [BK20160505]
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Vibrio parahaemolyticus is capable of surviving in biofilm communities attached to biotic and abiotic surfaces. The exopolysaccharide (EPS) plays a key role in the maturing of the biofilm. The VPA1403-1412 (cpsA-J) operon is responsible for EPS production in V. parahaemolyticus. The expression of cpsA-J is controlled by ScrABC, intracellular concentration of c-di-GMP, CpsS-CpsR-CpsQ regulatory cascade, and quorum sensing. The data presented here showed that H-NS activates the EPS-dependent bacterial colony morphology and the transcription of cpsQ and cpsA-J. H-NS has negative regulatory activity on scrABC transcription, and thereby may result in enhancing the intracellular concentration of c-di-GMP. Thus, a regulatory circuit involved in regulating cpsA-J/EPS production by H-NS, ScrABC and CpsQ was identified in V. parahaemolyticus.
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