Journal
MICRO & NANO LETTERS
Volume 13, Issue 9, Pages 1352-1357Publisher
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/mnl.2018.5206
Keywords
biological techniques; microfluidics; nanosensors; biosensors; DNA; electrochemical sensors; silicon; nanoporous materials; flow sensors; flow measurement; microsensors; silicon compounds; elemental semiconductors; in-flow label-free single molecule sensors; label-free single molecule detection capability; electrochemical sensing; in-flow label-free electrochemical detection; hydrodynamic flow; planar solid-state nanopore integrated microfluidic devices; DNA molecule sequencing; solid-state nanopore biosensors; graphene; biomolecule sensing; Si3N4-Si
Funding
- Turkish Ministry of Education
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Nanopore biosensors have attracted attention due to their label-free single molecule detection capability. To date, different materials and applications have been shown in the field, varying from Si3N4 to graphene and biomolecule sensing to DNA sequencing. Classical nanopore devices are composed of Si3N4 material supported on a Si wafer and the detection is largely based on electrochemical sensing using chambers of ml volumes on both sides of the nanopore device. In this study, in-flow label-free electrochemical detection of DNA molecules at single molecule level is shown using a classical Si3N4 nanopore device integrated into a microfluidic device. The layout of the device given here set the basics for future works and discussions regarding future microfluidic integrated solid-state nanopores and the behaviour of the molecule under the influence of hydrodynamic flow.
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