Journal
METHODS
Volume 149, Issue -, Pages 74-84Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2018.04.022
Keywords
Vagina; Metabolomics; Microbiome; Next generation sequencing; Mass spectrometry; Ambient ionisation; Point-of-care diagnostics; Mucosa
Funding
- Medical Research Council [MR/L009226/1]
- European Research Council [617896]
- Imperial College NIHR Biomedical Research Centre [58434]
- MRC [MR/L009226/1] Funding Source: UKRI
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There is increasing appreciation of the role that vaginal microbiota play in health and disease throughout a woman's lifespan. This has been driven partly by molecular techniques that enable detailed identification and characterisation of microbial community structures. However, these methods do not enable assessment of the biochemical and immunological interactions between host and vaginal microbiota involved in pathophysiology. This review examines our current knowledge of the relationships that exist between vaginal microbiota and the host at the level of the vaginal mucosal interface. We also consider methodological approaches to microbiomic, immunologic and metabolic profiling that permit assessment of these interactions. Integration of information derived from these platforms brings the potential for biomarker discovery, disease risk stratification and improved understanding of the mechanisms regulating vaginal microbial community dynamics in health and disease.
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