Journal
CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
Volume 22, Issue 4, Pages 689-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.chc.2013.06.003
Keywords
Schizophrenia; Structural MRI; Genetic high-risk; Prodrome; Early-onset schizophrenia; Childhood-onset schizophrenia
Categories
Funding
- NCRR NIH HHS [KL2 RR 025757, KL2 RR025757] Funding Source: Medline
- NIMH NIH HHS [MH081928, R21 MH092840, U01 MH081928, R01 MH065571, L30 MH091727, MH065571, MH092840] Funding Source: Medline
- PHS HHS [KO2 01180, 78113, R01 64023] Funding Source: Medline
Ask authors/readers for more resources
This article reviews the literature on structural magnetic resonance imaging findings in pediatric and young adult populations at clinical or genetic high-risk for schizophrenia and early-onset schizophrenia. The implications of this research are discussed for understanding the pathophysiology of schizophrenia and for early intervention strategies. The evidence linking brain structural changes in prepsychosis development and early-onset schizophrenia with disruptions of normal neurodevelopmental processes during childhood or adolescence is described. Future directions are outlined for research to address knowledge gaps regarding the neurobiological basis of brain structural abnormalities in schizophrenia and to improve the usefulness of these abnormalities for preventative interventions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available