Journal
METABOLIC ENGINEERING
Volume 50, Issue -, Pages 109-121Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2018.05.006
Keywords
Bacillus subtilis; Metabolic engineering; Microbial cell factories; Industrial applications; Synthetic biology
Categories
Funding
- National Natural Science Foundation of China [31622001, 31671845, 31600068]
- Natural Science Foundation of Jiangsu Province [BK20160176]
- 111 Project [111-2-06]
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Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing clear inherited backgrounds, having mature genetic manipulation methods, and exhibiting robustness in large-scale fermentations. Till date, B. subtilis has been identified as attractive hosts for the production of recombinant proteins and chemicals. By applying various systems and synthetic biology tools, the productivity features of B. subtilis can be thoroughly analyzed and further optimized via metabolic engineering. In the present review, we discussed why B. subtilis is the primary organisms used for metabolic engineering and industrial applications. Additionally, we summarized the recent advances in systems and synthetic biology, engineering strategies for improving cellular performances, and metabolic engineering applications of B. subtilis. In particular, we proposed emerging opportunities and essential strategies to enable the successful development of B. subtilis as microbial cell factories.
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