4.2 Article

New selective cyclizations of alk-4-ynals with primary amines and azoles: one-pot synthesis of 2-azolylpyrrolidines and 3-iminocyclopentene's

Journal

MENDELEEV COMMUNICATIONS
Volume 28, Issue 2, Pages 123-125

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.mencom.2018.03.002

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Funding

  1. Russian Foundation for Basic Research [15-03-08195 A]

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One-pot cyclization of alk-4-ynals with primary aliphatic amines and azoles in DMSO under the action of KOH affords 1-alkyl-2-azolyl-5-arylmethylidenepyrrolidines. Similar pro-cesses with lithium monoalkylamides in THE give rise to 3-iminocyclopentenes.

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