Journal
MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 113, Issue 8, Pages -Publisher
FUNDACO OSWALDO CRUZ
DOI: 10.1590/0074-02760180098
Keywords
bifunctional beta-lactamase; antibiotic resistance; health surveillance
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Funding
- CAPES
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beta-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to beta-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two beta-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against beta-lactams consistent with two functional domains was found. Here, we present the results of searches in the non-redundant NCBI protein database that revealed the existence of a group of homologous bifunctional beta-lactamases in the genomes of environmental bacteria. These findings suggest that bifunctional beta-lactamases are widespread in nature; these findings also raise concern that bifunctional beta-lactamases may be transferred to bacteria of clinical importance through lateral gene transfer mechanisms.
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