Journal
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Volume 29, Issue 6, Pages 971-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2015.07.003
Keywords
Head and neck cancer; Squamous cell carcinoma; Molecular biology; Targeted therapy; Synthetic lethality; Genomic sequencing; Intratumor heterogeneity
Categories
Funding
- NIDCR NIH HHS [R01 DE022087] Funding Source: Medline
Ask authors/readers for more resources
In spite of a rapidly expanding understanding of head and neck tumor biology and optimization of radiation, chemotherapy, and surgical treatment modalities, head and neck squamous cell carcinoma (HNSCC) remains a major cause of cancer-related morbidity and mortality. Although our biologic understanding of these tumors had largely been limited to pathways driving proliferation, survival, and differentiation, the identification of HPV as a major driver of HNSCC and genomic sequencing analyses has dramatically influenced our understanding of tumor biology and approach to therapy. Here, we summarize molecular aspects of HNSCC biology and identify promising areas for potential diagnostic and therapeutic agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available