Three New Lignan Derivatives from Lindera glauca (Siebold et Zucc.) Blume

Two new aryl-tetralin lignan glycosides, linderanosides A and B (1 and 2, resp.), and a new dihydrobenzofuran neolignan glycoside, linderanoside C (3), together with five known lignan derivatives (4-8) were isolated from the trunk of Lindera glauca. The structures of these new compounds were determined through spectroscopic analyses, including extensive 2D-NMR data and acid hydrolysis. The absolute configurations of the compounds were clarified by circular dichroism (CD) spectroscopic studies. Compounds 1-8 were evaluated for their cytotoxicity against A549 (non-small cell lung adenocarcinoma), SK-OV-3 (ovarian cancer cells), A498 (human kidney epithelial cells), and HCT-15 (colon cancer cells) human tumor cell lines using sulforhodamine B assays in vitro.