Journal
MEDICINAL RESEARCH REVIEWS
Volume 39, Issue 1, Pages 328-348Publisher
WILEY
DOI: 10.1002/med.21515
Keywords
animal model; awareness; epidemiology; molecular target; nonalcoholic fatty liver disease (NAFLD)
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Funding
- National Science and Technology Support Project [2014BAI02B01, 2015BAI08B01]
- National Science Fund for Distinguished Young Scholars [81425005]
- Key Collaborative Project of the National Natural Science Foundation [91639304]
- National Key Research and Development Program [2013YQ030923-05]
- National Natural Science Foundation [81330005, 81630011]
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Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide. Individuals with NAFLD have a high frequency of developing progressive liver disease and metabolism-related comorbidities, which result from of a lack of awareness and poor surveillance of the disease and a paucity of approved and effective therapies. Managing the complications of NAFLD has already begun to place a tremendous burden on healthcare systems. Although efforts to identify effective therapies are underway, the lack of validated preclinical NAFLD models that represent the biology and outcomes of human disease remains a major barrier. This review summarizes the characteristics and prevalence of the disease and the status of our understanding of its mechanisms and potential therapeutic targets.
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