Design and Synthesis of New Bile AcidSterol Conjugates Linked via 1,2,3-Triazole Ring

A new steroid conjugates have been obtained from bile acids and sterol derivatives using click chemistry'. Intermolecular 1,3-dipolar cycloaddition of the propargyl ester of bile acids (lithocholic, deoxycholic, and cholic acid) and azide derivatives of sterols (ergosterol and cholesterol) gave a new bile acidsterol conjugates linked with a 1,2,3-triazole ring. The structures of all products were confirmed by spectroscopic (H-1- and C-13-NMR, and FT-IR) analyses, mass spectrometry (ESI-MS), and in silico biological activity evaluation methods (PASS), as well as PM5 semiempirical methods.