Journal
HELVETICA CHIMICA ACTA
Volume 98, Issue 10, Pages 1337-1350Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.201500118
Keywords
Bile acids; Sterols; Click chemistry; 1; 2; 3-Triazole ring; Steroid conjugates
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A new steroid conjugates have been obtained from bile acids and sterol derivatives using click chemistry'. Intermolecular 1,3-dipolar cycloaddition of the propargyl ester of bile acids (lithocholic, deoxycholic, and cholic acid) and azide derivatives of sterols (ergosterol and cholesterol) gave a new bile acidsterol conjugates linked with a 1,2,3-triazole ring. The structures of all products were confirmed by spectroscopic (H-1- and C-13-NMR, and FT-IR) analyses, mass spectrometry (ESI-MS), and in silico biological activity evaluation methods (PASS), as well as PM5 semiempirical methods.
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