Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
Volume 169, Issue 4, Pages 353-360Publisher
WILEY
DOI: 10.1002/ajmg.c.31467
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Funding
- Health Resources and Services Administration
- US Department of Health and Human Services, Maternal and Child Health Bureau [T77MC09797-06]
- Brown University Leadership in Education in Behavioral Pediatrics training grant
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It has long been recognized that early adversity can have life-long consequences, and the extent to which this is true is gaining increasing attention. A growing body of literature implicates Adverse Childhood Experiences, including physical, sexual, and emotional abuse, in a broad range of negative health consequences including adult psychopathology, cardiovascular, and immune disease. Increasing evidence from animal, clinical, and epidemiological studies highlight the critical role of epigenetic programing, such as DNA methylation and histone modification, in altering gene expression, brain structure and function, and ultimately life-course trajectories. This review outlines our developing insight into the interplay between our human biology and our changing environment, and explores the growing evidence base for how interventions may prevent and ameliorate damage inflicted by toxic stress in early life. (c) 2015 Wiley Periodicals, Inc.
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