Journal
JOURNAL OF CHEMICAL SCIENCES
Volume 125, Issue 5, Pages 1161-1168Publisher
INDIAN ACAD SCIENCES
DOI: 10.1007/s12039-013-0473-z
Keywords
Iron(II); Schiff base; X-ray structure; DNA binding; DNA cleavage
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Funding
- Department of Science and Technology (DST), New Delhi, India [SR/FT/CS-83/2010]
- University of Burdwan
- Council for Scientific and Industrial Research (CSIR), New Delhi, India
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Synthesis and characterization of a mononuclear Fe(II) compound [Fe(L)](ClO4)(2) (1) [L = N-(1-pyridin-2-yl-phenylidene)-N'-[2-({2-[(1-pyridin-2-ylphenylidene)amino]ethyl}amino)ethyl] ethane-1,2-diamine] (1) is reported. 1 crystallizes in P-1 space group with a = 11.9241(3) , b = 12.1994(3) and c = 13.0622(4) . The binding property of the complex with DNA has been investigated using absorption and emission studies, thermal melting, viscosity experiments and circular dichroism studies. The binding constant (K (b)) and the linear Stern-Volmer quenching constant (K (sv)) of the complex have been determined as 3.5 x 10(3) M (-aEuro parts per thousand 1) and 2.73 x 10(4) M (-aEuro parts per thousand 1), respectively. Spectroscopic and hydrodynamic investigations revealed intercalative mode of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner.
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