Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 168, Issue 6, Pages 459-470Publisher
WILEY
DOI: 10.1002/ajmg.b.32341
Keywords
Attention-deficit; hyperactivity disorder; Conners Continuous Performance Test; adults; GWAS; SORCS2
Categories
Funding
- Ministerio de Economia y Competitividad [SAF2012-33484]
- AGAUR [2014SGR-0932, 2014SGR1357]
- Instituto de Salud Carlos III-FIS [PI11/00571, PI11/01629, PI12/01139]
- Miguel Servet [CP09/00119]
- Plan Nacional Sobre Droga (PNSD) [2011-0080]
- Departament de Salut, Government of Catalonia, Spain
- 7th Framework Programme for Research, technological Development and Demonstration, European Commission [AGGRESSOTYPE_FP7HEALTH2013/602805]
- European College of Neuropsycho-pharmacology
- Spanish 'Ministerio de Economia y Competitividad' [SAF2012-33484]
- Plan Nacional Sobre Drogas [2011-0080]
- Instituto de Salud Carlos III [CD14/00214]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca [AGAUR FI-DGR 2015]
- [FI-DGR 2015]
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Attention deficit is one of the core symptoms of the attention-deficit/hyperactivity disorder (ADHD). However, the specific genetic variants that may be associated with attention function in adult ADHD remain largely unknown. The present study aimed to identifying SNPs associated with attention function in adult ADHD and tested whether these associations were enriched for specific biological pathways. Commissions, hit-reaction time (HRT), the standard error of HRT (HRTSE), and intraindividual coefficient variability (ICV) of the Conners Continuous Performance Test (CPT-II) were assessed in 479 unmedicated adult ADHD individuals. A Genome-Wide Association Study (GWAS) was conducted for each outcome and, subsequently, gene set enrichment analyses were performed. Although no SNPs reached genome-wide significance (P<5E-08), 27 loci showed suggestive evidence of association with the CPT outcomes (P
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