Journal
MATRIX BIOLOGY
Volume 78-79, Issue -, Pages 272-283Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2018.01.022
Keywords
Neurogenesis; Neural stem cell; Perineuronal net; Hyaluronan
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Funding
- Congressionally Directed Medical Research Programs [P51 OD011092, MS160144]
- National Multiple Sclerosis Society [RG 4843A5/1]
- CDMRP [917570, MS160144] Funding Source: Federal RePORTER
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Adult neurogenesis in mammals is a tightly regulated process where neural stem cells (NSCs), especially in the subgranular zone (SGZ) of the hippocampal dentate gyrus, proliferate and differentiate into new neurons that form new circuits or integrate into old circuits involved in episodic memory, pattern discrimination, and emotional responses. Recent evidence suggests that changes in the hyaluronan (HA)-based extracellular matrix of the SGZ may regulate neurogenesis by controlling NSC proliferation and early steps in neuronal differentiation. These studies raise the intriguing possibility that perturbations in this matrix, including HA accumulation with aging, could impact adult neurogenesis and cognitive functions, and that alterations to this matrix could be beneficial following insults to the central nervous system that impact hippocampal functions. (C) 2018 Elsevier B.V. All rights reserved.
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