Journal
PHOTOACOUSTICS
Volume 1, Issue 3-4, Pages 62-67Publisher
ELSEVIER GMBH
DOI: 10.1016/j.pacs.2013.10.001
Keywords
Graphene; Photoacoustic tomography; Thermoacoustic tomography; Contrast agents; Microwave imaging
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Funding
- NIH Director's New Innovator Award [1DP2OD007394-01]
- Wallace H. Coulter Foundation
- NIH [R01 EB008085, R01 CA140220, R01 CA157277, R01 CA159959, U54 CA136398, DP1 EB016986 - NIH]
- Microphotoacoustics, Inc.
- Endra, Inc.
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In this work, graphene nanoribbons and nanoplatelets were investigated as contrast agents for photoacoustic and thermoacoustic tomography (PAT and TAT). We show that oxidized single- and multi-walled graphene oxide nanoribbons (O-SWGNRs, O-MWGNRs) exhibit approximately 5-10 fold signal enhancement for PAT in comparison to blood at the wavelength of 755 nm, and approximately 10-28% signal enhancement for TAT in comparison to deionized (DI) water at 3 GHz. Oxidized graphite microparticles (O-GMPs) and exfoliated graphene oxide nanoplatelets (O-GNPs) show no significant signal enhancement for PAT, and approximately 12-29% signal enhancement for TAT. These results indicate that O-GNRs show promise as multi-modal PAT and TAT contrast agents, and that O-GNPs are suitable contrast agents for TAT. (C) 2013 The Authors. Published by Elsevier GmbH.
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