Journal
NATURAL PRODUCT COMMUNICATIONS
Volume 8, Issue 12, Pages 1719-1720Publisher
NATURAL PRODUCTS INC
Keywords
Angiogenesis; Flavonoid; Subcritical extraction; Melia azedarach; Quercetin; Kaempferol
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Three flavonoid glycosides, 1 (rutin: quercetin 3-O-rutinoside), 2 (kaempferol 3-O-robinobioside) and 3 (kaempferol 3-O-rutinoside) were isolated from the subcritical water extracts of Melia azedarach leaves. Strong antiangiogenic activity of these compounds was observed in the in vivo assay using the chorioallantoic membrane (CAM) from growing chick embryos.
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