Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 91, Issue -, Pages 190-200Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2018.05.034
Keywords
Hydrogel; Osteoarthritis; Osteochondral defect; Subchondral bone; Berberine
Categories
Funding
- National Natural Science Foundation of China [81171739, 81101378, 81271971, 81271972, 31270997]
- Natural Science Fund of Zhejiang Province [Y2110372]
- Funds of Science and Technology Department of Zhejiang Province [2009C03014-1]
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents
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Degradation of the articular cartilage and structural remodeling of the subchondral bone are regarded as the two major pathological characteristics of osteoarthritis. This study aimed to investigate the effect of an interpenetrating polymer network (IPN) of a sodium hyaluronate and sodium alginate (HA/SA) scaffold combined with berberine (BER) on osteochondral repair. We first developed an IPN scaffold of HA/SA and evaluated its characteristics. Then, we analyzed the effect of the HA/SA scaffold combined with BER on the healing of osteochondral defects in vivo. Finally, we explored the mechanism of this system in osteochondral repair. The results showed that the system could simultaneously regenerate not only the cartilage but also the subchondral bone. Our results also revealed that the subchondral bone was partially repaired by activating the Wnt signaling pathway and the cartilage was protected from degeneration by the upregulation of autophagy. This study demonstrated that the combination of the IPN scaffold of HA/SA and BER is a promising strategy for the osteochondral defect regeneration.
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