Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 92, Issue -, Pages 447-452Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.06.072
Keywords
Collagen; Glycosaminoglycan; Dual layer; Vascular scaffold; Tissue engineering
Categories
Funding
- National Natural Science Foundation of China [21574059]
- Natural Science Foundation of Jiangsu Province [BK20170203]
- Fundamental Research Funds for the Central Universities [JUSRP11748]
- national first-class discipline program of Light Industry Technology and Engineering [LITE2018-20]
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A dual layer conduit, which consists of collagen I-hyaluronic acid (Col-HA, external layer) and collagen I-heparin (Col-HP, inner layer), has been developed. This conduit not only meets the structural requirement of nature blood vessel, but also presents favourable mechanical performance after crosslinking via EDC. In addition, its biological properties are evaluated through culturing with fibroblast cell (Cos-7) on Col-HA surface and vascular endothelial cell (HMEC) on Col-HP layer. Results demonstrate that the conduit can support Cos-7 and HMEC adhesion, proliferation and elongation on respective side. This dual layer conduit would be a new choice of artificial vascular scaffold and improve blood vessel regeneration for tissue engineering.
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