Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 92, Issue -, Pages 453-462Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.06.044
Keywords
Cisplatin; Dual targets; Redox stimulus-response; Photothermal conversion; Polymeric nanoparticles; Core-crosslinking
Categories
Funding
- National Natural Science Foundation of China [21371031, 21628101]
- International S&T Cooperation Program of China [2015DFG42240]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
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Functional drug delivery systems enabling various favorable characteristics including specific targets, efficient cellular uptake and controllable release. At present work, a folate and cRGD dual modified nanoparticles based on NIR light and glutathione dual stimuli-responsive release system was successfully prepared and which simultaneously deliver cisplatin and ICG to tumor sites to enhance controllability. The prepared nanoparticles showed a stable uniform spherical morphology of 77.59 nm particle size range in PBS (pH = 7.4, 25 degrees C) and the encapsulated cisplatin were rapidly released in acidic environment especially added glutathione (GSH) and NIR irradiation. Moreover, the prepared nanoparticles can be efficiently internalized by tumor cells through the enhanced dual targeted ligands (folate and cRGD) for ICG imaging. The cytotoxicity assays showed that the cells viability decreased to 1.95% (SGC-7901) when been exposed to NIR light, and which further decreased to 1.25% in MCF-7 cells. Thus, the prepared nanoparticles showed excellent performance for photothermal conversion therapy of tumor cells and especially on human breast tumor cells. Our research highlights the great potential of stimuli-responsive smart nanoparticles in biomaterial and nano-biomedicine.
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