Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 85, Issue -, Pages 18-26Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.12.006
Keywords
Microneedles; Transdermal delivery; Hypoglycemic effect; Diabetes
Categories
Funding
- National Natural Science Foundation of China [51373155]
- Natural Science Foundation of Zhejiang Province [LY18E030006]
- 521 Talents Training Plan in Zhejiang Sci-Tech University (ZSTU)
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To reduce the inconvenient and painful of subcutaneous needle injection, the calcium ion cross-linked alginate/maltose (Ca2+/Mg-Mal) composite microneedles have been fabricated by a template method. The as-prepared microneedles exhibited strong mechanical properties with the highest failure force around 0.41 N/needle. The biological activity and stability of loaded insulin in microneedles were investigated. Due to the good mechanical properties and excellent biocompatibility, the as-prepared microneedles have been applied for transdermal delivery of insulin on diabetic Sprague-Dawley (SD) rat models in vivo. After transdermal administration to the diabetic rats, the released insulin from biodegradable composite microneedles exhibit an obvious and effective hypoglycemic effect with relative pharmacological availability (RPA) and relative bioavailability (RBA) at 94.1 +/- 5.6% and 93.7 +/- 4.7% compared with that of subcutaneous injection route. This work suggests that as prepared Ca2+/Alg-Mal microneedles can be used to encapsulate insulin and have a potential application in diabetes treatment via transdermal ingestion.
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