Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 85, Issue -, Pages 57-67Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.12.019
Keywords
Calcium carbonate; Scaffold drug delivery; Tissue regeneration; In vivo biocompatibility; Tannic acid; Rat
Categories
Funding
- ERA-NET Rus Plus program
- RFBR [15-29-01172 ofi_m]
- Government of the Russian Federation [14.Z50.31.0004]
- Research Foundation Flanders (FWO), Belgium
- BOF UGent
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Designing advanced biomaterials for tissue regeneration with drug delivery and release functionalities remains a challenge in regenerative medicine. In this research, we have developed novel composite scaffolds based on polymeric polycaprolactone fibers coated with porous calcium carbonate structures (PCL/CaCO3) for tissue engineering and have shown their drug delivery and release in rats. In vivo biocompatibility tests of PCL/CaCO3 scaffolds were complemented with in vivo drug release study, where tannic acid (TA) was used as a model drug. Release of TA from the scaffolds was realized by recrystallization of the porous vaterite phase of calcium carbonate into the crystalline calcite. Cell colonization and tissue vascularization as well as transplantability of developed PCL/CaCO3 + TA scaffolds were observed. Detailed study of scaffold transformations during 21-day implantation period was followed by scanning electron microscopy and X-ray diffraction studies before and after in vivo implantation. The presented results demonstrate that PCL/CaCO3 scaffolds are attractive candidates for implants in bone regeneration and tissue engineering with a possibility of loading biologically active molecules and controlled release.
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