Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 90, Issue -, Pages 531-538Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2018.04.035
Keywords
Graphitic carbon nitride; Photo dynamic therapy; Bio-imaging; Cytotoxicity; Reactive oxygen species
Categories
Funding
- R&D Convergence Program of NST (National Research Council of Science & Technology) of Republic of Korea [CAP-15-02-KBSI]
- Inha University WCSL research grant
Ask authors/readers for more resources
Organic graphitic carbon nitride nanoparticles (NP-g-CN), less than 30 nm in size, were synthesized and evaluated for photodynamic therapy (PDT) and cell imaging applications. NP-g-CN particles were prepared through an intercalation process using a rod-like melamine-cyanuric acid adduct (MCA) as the molecular precursor and a eutectic mixture of LiCI-KCI (45:55 wt%) as the reaction medium for polycondensation. The nano-dimensional NP-g-CN penetrated the malignant tumor cells with minimal hindrance and effectively generated reactive oxygen species (ROS) under visible light irradiation, which could ablate cancer cells. When excited by visible light irradiation (lambda > 420 nm), NP-g-CN introduced to HeLa and cos-7 cells generated a significant amount of ROS and killed the cancerous cells selectively. The cytotoxicity of NP-g-CN was manipulated by altering the light irradiation and the BP-g-CN caused more damage to the cancer cells than normal cells at low concentrations. As a potential non-toxic organic nanomaterial, the synthesized NP-g-CN are biocompatible with less cytotoxicity than toxic inorganic materials. The combined effects of the high efficacy of ROS generation under visible light irradiation, low toxicity, and bio-compatibility highlight the potential of NP-g-CN for PDT and imaging without further modification.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available