Journal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume 54, Issue 10, Pages 7075-7081Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.13-12474
Keywords
reticular pseudodrusen; spectral-domain optical coherence tomography; choroidal layer; early age-related macular degeneration; retinal ischemia
Categories
Funding
- Doris Duke Charitable Foundation
- Robert L. Burch III Fund Columbia University, New York, New York
- New York Stem Cell Science [R01EY018213, N09G-302]
- Foundation Fighting Blindness
- Schneeweiss Stem Cell Fund
- Tistou and Charlotte Kerstan Foundation
- Crowley Family Fund
- Joel Hoffman Scholarship
- Barbara and Donald Jonas Family Fund
- Professor Gertrude Rothschild Stem Cell Foundation
Ask authors/readers for more resources
PURPOSE. To compare choroidal thickness (CT) measurements in early AMD between patients with and without reticular pseudodrusen (RPD) using spectral-domain optical coherence tomography (SD-OCT). METHODS. This cross-sectional study examined 84 age-and sex-matched AMD patients (40 RPD [63 eyes], 44 non-RPD [75 eyes]). Fundus photographs and scanning laser ophthalmoscopy images were graded to identify RPD and non-RPD groups by three retinal specialists (MO, SY, SB) who were masked to corresponding SD-OCTs. CT at the fovea and 2400 to 3000 mu m superior and inferior to the fovea was measured on SD-OCT by a grader (AG) and reviewed by a retinal specialist (SB). Only images with a clear posterior choroidal margin were analyzed (six eyes excluded due to poor image quality), and enhanced depth imaging SD-OCT was used when available (20 of 138 eyes). Greatest retinal thickness (RT) on horizontal foveal SD-OCT was also recorded. RESULTS. Mean CTs in the superior, foveal, and inferior macula in RPD (191.3 mu m +/- 57.9 SD, 176.3 mu m +/- 60.5 SD, 179.7 mu m +/- 56.24 SD) were significantly less than that of non-RPD (228.0 mu m +/- 66.1 SD, 216.5 mu m +/- 70.3 SD, 224.4 mu m +/- 71.9 SD; P = 0.0010, P = 0.0005, P = 0.0001, respectively), as was greatest RT (P = 0.0301). CONCLUSIONS. CT was thinner throughout the macula in the RPD group as compared with the non-RPD group. The current analysis supports an association between RPD and a thinned choroidal layer and is consistent with a choroidal etiology of RPD. CT may be integral to understanding RPD, and may be helpful in stratifying AMD progression risk.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available