Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 89, Issue -, Pages 119-127Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2018.03.029
Keywords
Bioactive glass; Gelatin methacryloyl; Composites hydrogels; Bone tissue engineering
Categories
Funding
- National Natural Science Foundation of China [U1501245, 51672088]
- Natural Science Foundation of Guangdong Province [2015A030310034]
- Science and Technology Innovation Team Project of Foshan, China [2015IT100062]
Ask authors/readers for more resources
In recent years, gelatin-based composites hydrogels have been intensively investigated because of their inherent bioactivity, biocompatibility and biodegradability. Herein, we fabricated photocrosslinkable biomimetic composites hydrogels from bioactive glass (BG) and gelatin methacryloyl (GeIMA) by a sequential physical and chemical crosslinking (gelation + UV) approach. The results showed that the compressive modulus of composites hydrogels increased significantly through the sequential crosslinking approach. The addition of BG resulted in a significant increase in physiological stability and apatite-forming ability. In vitro data indicated that BG/GelMA composites hydrogels promoted cell attachment, proliferation and differentiation. Overall, the BG/GelMA composites hydrogels combined the advantages of good biocompatibility and bioactivity, and had potential applications in bone regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available