Development of temozolomide coated nano zinc oxide for reversing the resistance of malignant glioma stem cells

Recentiy most of the researchers have turned their interest towards plant mediated synthesis of metal nanoparticles to avoid several environmental toxicants. In this manuscript, we have discussed the ecofriendly syntheses of zinc oxide nanoparticles (ZnO NPs) were achieved using Glycyrrbiza glabra (G. glabra) seed aqueous extract. The green synthesized ZnO NPs were characterized using analytical techniques like XRD, TEM, particle size histogram and Zeta potential. From the results, it was found that the green synthesized ZnO NPs were around 35 nm in size with inregular spherical shape. The Zeta potential study of ZnO NPs was resulted to be high stabile with electronegative charge around - 56.3 mV. Further the G. glabra seed aqueous extract mediated synthesis of ZnO NPs were subjected to treat human glioblastoma cells with the help of temozolomide (TMZ) a commercially available drug by the method of MTT cell viability assay. The results stated that the ZnO NPs shows IC(50)value around 30 mu g/mL results significantly. The plausible mechanism behind the mortality rate was also discussed in this manuscript. (c) 2017 Published by Elsevier B.V.