Preparation of multifunctional cascade iron oxide nanoparticles for drug delivery

A novel pH sensitive magnetic multifunctional nanomaterial was prepared for sustained release of drugs. Adamantane derivative (ADMA) was covalently attached to the iron (II, III) oxide nanoparticles. On the basis of host-guest interactions, a stable inclusion complex between adamantane and succinyl beta-cyclodextrin (CD-COOH) with ionically bonded polyamidoamnie dendrimer was formed. The dendrimer was used as a drug carrier of ibuprofen (IBU) and methotrexate (MTX), model therapeutic agents. In pH 7.4 IBU and MTX were released from dendrimer in sustained manner with Korsmeyer-Peppas kinetic model and case I transport mechanism. In pH 1.2, only a little amount of IBU and MTX was released, while acidic environment contributed to the degradation of the inclusion complex (ADMA and CD-COOH) and thereby releasing of antiviral ADMA drug. (C) 2018 Elsevier B.V. All rights reserved.