Journal
MATERIALS CHEMISTRY AND PHYSICS
Volume 216, Issue -, Pages 14-21Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2018.05.038
Keywords
Hydrogel; Microstructure; Poly vinyl alcohol; Freeze-thaw; Swelling kinetics
Categories
Funding
- Universidad Nacional del Litoral (UNL)
- Universitat Ulm
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
- Deutsch Akademische Austausch-Dienst (DAAD)
- Centro Universitario Argentino-Aleman (CUAA)
- Agencia Nacional de Promocidn Cientifica y Tecnologica (ANPCyT) - Fondo para la Investigacian Cientifica y Tecnologica (FONCYT) [PICT 2015 1785, PIP 1118]
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PVA hydrogels obtained by freeze-thaw technique find important applications in regenerative medicine and controlled drug delivery technologies. The novelty of this contribution is the establishment of the cross-dependency of kinetics and thermodynamics parameters of swelling and dissolution of PVA hydrogels with the freeze-thaw process main variables. The work also establishes cross-correlations between the freeze-thaw process conditions, the gel microstructure and the properties of obtained hydrogel/hydrosoluble PVA materials. The conditions of the freeze-thaw process were selected by following an experimental design. The time evolution of the water up-take of PVA hydrogels was measured and used as main raw data generator. A 4-D surface response of the swelling and dissolution parameters in the space of freeze-thaw process variables was obtained and analyzed in terms of the resulting hydrogel and hydrosoluble polymeric structures. The 4-D surface response in the space of freeze-thaw process variables can predict very precisely the swelling and dissolution of PVA systems and their conditions for developing fully crosslinked hydrogel networks to fully hydrosoluble polymeric bodies.
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