Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 12, Pages 6391-6396Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b00348
Keywords
antigen; chemisorption; immune response; lyophilization; nanoparticle
Funding
- National Natural Science Foundation of China [81273452]
- Elite Faculty S&R Project Startup Fund of AMU [XJ201206]
- Fundamental Research Funds for the Central Universities (HUT)
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The phospholipid bilayer-coated aluminum nanoparticles (PLANs), formed via chemisorption, were prepared by reverse ethanol injection-lyophilization (REIL) utilizing the phosphophilicity of aluminum. The anhydrous antigen-loaded PLANs obtained by REIL proved stable, satisfying using the controlled-temperature-chain instead of the integrated cold-chain for distribution, and could be rehydrated to reconstitute instantly an aqueous suspension of the antigen-PLANs, which were more readily taken up by antigen-presenting cells and, when given subcutaneously to mice, induced more robust antigen-specific humoral and cellular immunoresponses but less local inflammation than the antigen-alum. Thus, the PLANs are a useful vaccine adjuvant-delivery system with advantages over the widely used naked alum.
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