Journal
MARINE DRUGS
Volume 16, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/md16070235
Keywords
bioactive peptides; green seaweeds; interleukin 10; TLR2; TLR4; NF kappa B
Categories
Funding
- Ministry of Economy and Competitivity
- Fondo Europeo de Desarrollo Regional FEDER funds [SAF2017-88457-R, AGL2017-85270-R, BFU2014-57736-P, AGL2014-58883-R]
- Junta de Andalucia [CTS235, CTS164]
- University of Granada (Contrato Puente Program-Plan Propio)
- Ministry of Education [Spain]
- Instituto de Salud Carlos III
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Hydrolysates of food protein sources have immunomodulatory effects, which are of interest for use as functional foods. In this study, we have characterized the immune regulatory effect on rat splenocytes, macrophages and T lymphocytes of Ulva spp. hydrolysates and their peptide fractions with or without in vitro gastrointestinal digestion and/or ultrafiltration. IL-10 was induced in almost all conditions and cell types obtained from wild type animals. The induction was in general increased by ultrafiltration and in vitro gastrointestinal digestion. TNF was also induced in basal conditions. In turn, TNF and IFN-gamma production was attenuated by the hydrolysate products in lipopolysaccharide or concanavalin A immune stimulated cells. Inhibitors for the activation of NF kappa B, MAPK p38 and JNK inhibited IL-10 induction in rat splenocytes. The response was dramatically attenuated in TLR4(-/- )cells, and only modestly in TLR2(-/-) cells. Food peptides from Ulva spp. genus exert anti-inflammatory effects in immune cells mediated by TLR4 and NF kappa B. Similarity with the immunomodulatory profile of protein hydrolysates from other sources suggests a common mechanism.
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