Journal
MARINE DRUGS
Volume 16, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/md16010025
Keywords
Penicillium steckii; tanzawaic acid derivatives; lipid-lowering activity
Categories
Funding
- National Natural Science Foundation of China [21372208]
- Shandong Provincial Natural Science Fund for Distinguished Young Scholars [JQ201422]
- Qingdao National Laboratory for Marine Science and Technology [2015ASTP-ES09, 2015ASKJ02]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Shandong province key research and development program [2016GSF201204]
- Fundamental Research Funds for the Central Universities [201564026]
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Seven new polyketides, named tanzawaic acids R-X (1-6, 11), along with seven known analogues (7-10 and 12-14), were isolated from Penicillium steckii HDN13-279. Their structures, including the absolute configurations, were elucidated by NMR, MS, X-ray diffraction, circular dichroism (CD) analyses and chemical derivatization. Five compounds (2, 3, 6, 10 and 12) significantly decreased the oleic acid (OA)-elicited lipid accumulation in HepG2 liver cells at the concentration of 10 M, among which, four compounds (3, 6, 10 and 12) significantly decreased intracellular total cholesterol (TC) levels and three Compounds (3, 6, and 10) significantly decreased intracellular triglyceride (TG) levels. Moreover, the TG-lowering capacities of compounds 6 and 10 were comparable with those of simvastatin, with the TG levels being nearly equal to blank control. This is the first report on the lipid-lowering activity of tanzawaic acid derivatives.
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