Journal
MARINE DRUGS
Volume 16, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/md16020061
Keywords
Chaetomium; chaephilone; chaetoviridide; antimicrobial; cytotoxic
Categories
Funding
- COMRA program [DY135-B-01]
- Scientific Research Foundation of Third Institute of Oceanography SOA [2017001]
- International Science & Technology Cooperation Program of China [2015DFA20500]
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Four novel compounds, chaephilone C (1), chaetoviridides A-C (2-4), were obtained from the culture of a deep sea derived fungus Chaetomium sp. NA-S01-R1, together with four known compoundschaetoviridin A (5), chaetoviridine E (6), chaetomugilin D (7) and cochliodone A (8). Their structures, including absolute configurations, were assigned based on NMR, MS and time-dependent density functional theory (TD-DFT) ECD calculations. A plausible biogenetic pathway for compounds 1-3 was proposed. Compounds 2 and 3 exhibited antibacterial activities against Vibrio rotiferianus and Vibrio vulnificus. Compounds 1, 3 and 4 displayed similar anti-methicillin resistant Staphylococcus aureus (anti-MRSA) activities in comparison to chloramphenicol. Compound 2 showed the most potent cytotoxic activities towards the Hep G2 cell and compounds 1 and 3 demonstrated relatively stronger cytotoxic activities than the other compounds against the HeLa cell.
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