Journal
MARINE DRUGS
Volume 16, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/md16020047
Keywords
pyrazines; alkaloids; Palythoa tuberculosa; anti-lymphangiogenesis
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Funding
- Ministry of Science and Technology, Taiwan [MOST106-2320-B-037-016, MOST 103-2320-B-037-005-MY2]
- Ministry of Health and Welfare, Taiwan (Health and Welfare Surcharge of Tobacco Products) [MOHW106-TDU-B-212-144007]
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Three new compounds, tuberazines A-C (1-3), and eleven known compounds (4-14) were obtained from the ethanolic extract of Taiwanese zoanthid Palythoa tuberculosa. Compounds 1-4 are rare marine natural products with a pyrazine moiety, and compound 5 is a tricyclic tryptamine derivative isolated from nature for the first time. The structures of all isolated metabolites were determined by analyzing their IR, Mass, NMR, and UV spectrometric data. The absolute configuration of 1 was confirmed by comparing the trend of experimental electronic circular dichroism (ECD) with calculated ECD spectra. The anti-lymphangiogenic activities of new compounds were evaluated in human lymphatic endothelial cells (LECs). Of these, new compound 3 displayed the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs.
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