Journal
MALARIA JOURNAL
Volume 17, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12936-018-2243-3
Keywords
Plasmodium vivax; Transmission blocking vaccine; Premonition; Asymptomatic parasitaemia
Categories
Funding
- United States Public Health Service
- National Institute of Allergy and Infectious Diseases [T32AI007036, U19AI089681]
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Plasmodium vivax remains an important cause of morbidity and mortality across the Americas, Horn of Africa, East and South East Asia. Control of transmission has been hampered by emergence of chloroquine resistance and several intrinsic characteristics of infection including asymptomatic carriage, challenges with diagnosis, difficulty eradicating the carrier state and early gametocyte appearance. Complex human-parasite-vector immunological interactions may facilitate onward infection of mosquitoes. Given these challenges, new therapies are being explored including the development of transmission to mosquito blocking vaccines. Herein, the case supporting the need for transmission-blocking vaccines to augment control of P. vivax parasite transmission and explore factors that are limiting eradication efforts is discussed.
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