Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 39, Issue 16, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201800364
Keywords
branching; glyco-polymers; hyperbranched; protein interactions; pseudodendrimers
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Funding
- DAAD - IIT Master Sandwich Scholarship
- Scholarship Program for the Promotion of Early-Career Female Scientists of TU Dresden
- Leibniz-Institut fur Polymerforschung Dresden e.V.
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Molar mass and end group number of a hyperbranched polyester are significantly increased by its transformation to a pseudodendrimer. Three generations of pseudodendrimers are obtained from hyperbranched aliphatic polyester core by modification with a protected AB*(2) monomer. A sequence of protection and deprotection steps leads to OH-terminated pseudodendrimers. NMR studies confirm maximum degree of branching in the first generation, which slightly decreases in the next two generations. Uniform, dense molecular structure formation was confirmed by MD simulation. Further modification to glyco-pseudodendrimers was performed with alpha-D-mannose leading to high molar masses and dense distribution of sugar units. The interaction of these sugar units with a plant lectin concanavalin A (Con A) was investigated using dynamic light scattering and cryogenic transmission electron microscopy. The protein-interaction studies of the glyco-pseudodendrimers confirm a loose network with Con A. The interaction activity depends on the generation number and modification degree.
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