Journal
MACROMOLECULAR BIOSCIENCE
Volume 18, Issue 6, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201800011
Keywords
cytotoxicity; drug release; local chemotherapy; paclitaxel; PLA; PEG fibers
Funding
- Grant Agency of the Czech Republic [16-04863S]
- Ministry of Education, Youth and Sports of the Czech Republic [BIOCEV-FAR LQ1604, CZ.1.05/1.1.00/02.0109]
- Ministry of Health of the Czech Republic
- University Hospital Motol, Prague, Czech Republic [00064203]
- Charles University, Prague, Czech Republic [GA UK 307115, SVV 260440]
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Local application of anticancer agents prolongs the presence time and increases the concentration of drug in the target place and therefore may reduce serious side effects compared to drug systemic administration. The preparation of fibrous materials of polylactide (PLA) and polyethylene glycol (PEG) loaded with paclitaxel (PTX, 1 or 10 wt%) is presented. Scanning electron microscopy proves that PTX is homogeneously incorporated into the fibers. The addition of PEG of various molecular weights (6, 20, or 35 kDa) ensures the release of significantly higher amounts of hydrophobic PTX in a prolonged release time compared to the fibers containing PTX only. Present PLA-PEG fibrous carriers can serve as a drug depot for PTX since they exhibit significant toxicity for cancer cell lines in several-day experiment. They are promising for local recurrence therapy, where the initial release is efficient to kill tumor cells and continued release can prevent their subsequent proliferation.
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