Journal
MACROMOLECULAR BIOSCIENCE
Volume 18, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201700305
Keywords
hydrogel; hydroxybutyl chitosan; oral delivery; thermo; pH double sensitive
Funding
- National Natural Science Foundation of China [81671828]
- China Postdoctoral Science Foundation [2016M592246]
- Taishan Scholar Program, China
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A series of thermo/pH sensitive N-succinyl hydroxybutyl chitosan (NSHBC) hydrogels with different substitution degrees of succinyl are prepared for drug delivery. Rheology analysis shows that the gelation temperature of NSHBC hydrogels is 3.8 degrees C higher than that of hydroxybutyl chitosan (HBC) hydrogels. A model drug bovine serum albumin (BSA) is successfully loaded and released. NSHBC hydrogels show excellent pH sensitivity drug release behaviors. After incubation for 24 h, 93.7% of BSA is released from NSHBC hydrogels in phosphate buffer saline (PBS) (pH 7.4), which is significantly greater than that of 24.6% at pH 3.0. In contrast, the release rate of BSA from HBC is about 70.0% at pH 3.0 and 7.4. Thus, these novel hydrogels have the prominent merits of high adaptability to soluble drugs and pH sensitivity triggered release, indicating that NSHBC hydrogels have promising applications in oral drug delivery.
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