Journal
LUNG CANCER
Volume 124, Issue -, Pages 260-269Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2018.07.001
Keywords
Antibody drug conjugate; Non-small-cell lung cancer; Small-cell lung cancer; Mesothelioma; Thoracic malignancies
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Funding
- University of Colorado Lung Cancer SPORE [P50CA058187]
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Antibody drug conjugates (ADCs) have the potential to alter the efficacy: toxicity ratio of cytotoxic therapy utilizing surface markers on cancer cells as antibody targets to preferentially deliver toxic payloads to tumor cells while limiting systemic toxicity. Multiple ADCs, differing in their antibody targets, cytotoxic payloads and linker molecules are currently being evaluated in non-small-cell lung cancer, small-cell lung cancer and malignant pleural mesothelioma. Here we review the available data in thoracic malignancies and the potential issues influencing the efficacy and toxicity of these approaches.
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