Journal
LIFE SCIENCES
Volume 196, Issue -, Pages 69-76Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2018.01.016
Keywords
Magnolol; Colitis; Dextran sulphate sodium; Inflammation; Mucosal damage
Funding
- Key Project of Chinese National Programs for Research and Development [2016YFD0501009]
- National Natural Science Foundation of China [31472248, 31572582]
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Magnolol, the main and active ingredient of the Magnolia officinalis, has been widely used in traditional prescription to the human disorders. Magnolol has been proved to have several pharmacological properties including anti-bacterial, anti-oxidant and anti-inflammatory activities. However, the effects of magnolol on ulcerative colitis (UC) have not been reported. The aim of this study was to investigate the protective effects and mechanisms of magnolol on dextran sulphate sodium (DSS)-induced colitis in mice. The results showed that magnolol significantly alleviated DSS-induced body weight loss, disease activities index (DAI), colon length shortening and colonic pathological damage. In addition, magnolol restrained the expression of TNF-alpha, IL-1 beta and IL-12 via the regulation of nuclear factor-kappa B (NF-kappa B) and Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) pathways. Magnolol also enhanced the expression of ZO-1 and occludin in DSS-induced mice colonic tissues. These results showed that magnolol played protective effects on DSS-induced colitis and may be an alternative therapeutic reagent for colitis treatment.
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