Journal
LEUKEMIA & LYMPHOMA
Volume 60, Issue 2, Pages 385-394Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2018.1474522
Keywords
Cardiotoxicity after cancer therapy; ALL; AML; congestive heart failure; anthracycline-related cardiotoxicity; irradiation
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Funding
- TSUF from Hospital for Sick Children Research Institute
- Northbridge cancer research fellowship from the Garron Family Cancer Center, Toronto
- American Society of Hematology Clinical Research Training Institute award (2015-2016)
- Institute for Clinical Evaluative Sciences (ICES)
- Ontario Ministry of Health and Long-Term Care (MOHLTC)
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The purpose was to describe the incidence and risk factors of congestive heart failure (CHF) among children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). We included 2053 children (<= 18 years) with first primary ALL and AML diagnosed 1992-2010 and registered in the Pediatric Oncology Group of Ontario Networked Information System. We identified CHF events through linked administrative databases. At 10 years, the cumulative incidence of CHF was 1.7% in ALL and 7.5% in AML. Factors associated with CHF in ALL were female gender, age <1 year at cancer diagnosis, irradiation and cumulative anthracycline dose >= 250 mg/m(2). Irradiation was the only risk factor in AML patients. Of the 23 patients with CHF during active therapy, one developed CHF following treatment completion. Incidence of CHF were 1.7% in ALL and 7.5% in AML. Most with CHF during active therapy did not develop CHF after treatment completion.
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