Journal
LETTERS IN DRUG DESIGN & DISCOVERY
Volume 16, Issue 1, Pages 29-35Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570180815666180326150827
Keywords
Difluoromethylpyrazole; alkyl chain; nematicidal activity; synthesis; docking; Meloidogyne incognita
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Funding
- Zhejiang Provincial Science Foundation of China [LY16C140007]
- Research Institute Special Program of Department of Science and Technology of Zhejiang Province [2015F50030]
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Background: A series of novel 2,6-dichloro-4-(trifluoromethyl)phenyl)-3-(difluoromethyl)-1H-pyrazole-4-carboxamide derivatives were designed and synthesized. Methods: All the title compounds were confirmed by H-1 NMR and MS. Results and Conclusion: The primarily nematicidal activity results indicated that some of them exhibited moderate control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita.
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