Journal
LASERS IN SURGERY AND MEDICINE
Volume 50, Issue 5, Pages 491-498Publisher
WILEY
DOI: 10.1002/lsm.22810
Keywords
photodynamic therapy; proteotoxic injury; oxidative stress; proteostasis; stress response pathways; stress signaling networks; cryptic antigen expression
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The insult delivered by photodynamic therapy (PDT) in treated cells is oxidative stress. The main burden threatening survival of PDT-treated cells is proteotoxic damage that jeopardizes proteostasis in these cells. For dealing with this type of proteostasis impairment, cells have developed protection mechanisms operating by signaling networks. This review will outline various components of signaling networks that can be engaged in stressed cells with highlighting the emerging aspects relevant to response to PDT. It will be also shown how the well known inflammatory/immune response associated with PDT is also based on the activity of these stress signaling networks. Lasers Surg. Med. 50:491-498, 2018. (c) 2018 Wiley Periodicals, Inc.
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