Journal
LABORATORY INVESTIGATION
Volume 98, Issue 5, Pages 582-588Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41374-017-0004-5
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Funding
- Fondation pour la Recherche Medicale (FRM) [DPM20121125557]
- Groupement des Entreprises Francaises contre le Cancer (GEFLUC)
- Canceropole IdF [2015-1-EMERG-25-INSERM 6-1]
- CMIRA Explo'ra doc fellowship of the Region Rhone Alpes
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Mitochondrial nucleoside diphosphate kinase (NDPK-D; synonyms: NME4, NM23-H4) represents the major mitochondrial NDP kinase. The homohexameric complex emerged as a protein with multiple functions in bioenergetics and phospholipid signaling. It occurs at different but precise mitochondrial locations and can affect among other mitochondrial shapes and dynamics, as well as the specific elimination of defective mitochondria or cells via mitophagy or apoptosis. With these various functions in cell homeostasis, NDPK-D/NME4 adds to the group of so-called moonlighting (or gene sharing) proteins.
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