Journal
LAB ON A CHIP
Volume 18, Issue 13, Pages 1928-1935Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8lc00371h
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Funding
- Government of Canada through Genome Canada
- Ontario Genomics Institute [OGI-077]
- Canadian Institutes of Health Research [148415]
- Natural Sciences and Engineering Research Council of Canada [2016-06090]
- Province of Ontario through the Ministry of Research, Innovation and Science [RE-GAPP-6408]
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Integrated devices for automated nucleic acid testing (NAT) are critical for infectious disease diagnosis to be performed outside of centralized laboratories. The gold standard methods for NAT are enzymatic amplification methods like the polymerase chain reaction that typically require expensive equipment and highlytrained personnel, limiting use in low-resource settings. A low-cost, integrated, rapid, portable and userfriendly point-of-care (POC) nucleic acid diagnostic device will improve the accessibility of NAT. Here, we present a fully integrated and simple-to-use POC device operated by a passive fluidic method that is able to perform a sequential multi-step assay to detect viral nucleic acids in blood. This simple device enabled the rapid detection of hepatitis C virus in blood in approximately 30 minutes with minimal sample handling by the user.
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