Journal
KIDNEY INTERNATIONAL
Volume 93, Issue 5, Pages 1038-1040Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2018.01.012
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Funding
- NIDDK NIH HHS [R01 DK081423] Funding Source: Medline
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Kidney stones is increasingly associated with obesity. With an increasing prevalence of obesity and metabolic syndrome in the past 30 years, urinary oxalate has significantly increased. However, its underlying pathophysiologic mechanisms of hyperoxaluria have not been fully explored. This preclinical study suggests that hyperoxaluria in obesity depends on a complex network of inflammatory responses linked to metabolic outcome. The future mechanistic and clinical investigations must be targeted at elucidating the pathogenetic role of inflammation in obesity induced hyperoxaluria. Copyright (C) 2018, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
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