Journal
3RD INTERNATIONAL ADVANCES IN APPLIED PHYSICS AND MATERIALS SCIENCE CONGRESS
Volume 1569, Issue -, Pages 466-470Publisher
AMER INST PHYSICS
DOI: 10.1063/1.4849317
Keywords
Calcium Phosphate Porous Composites; Calcium Phosphate Porous Ceramics; In vivo studies
Funding
- Bulgarian Ministry of Education, Youth and Science [DTK 02-70/2009]
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Two types of calcium phosphate materials prospective as bone implants were prepared in the shape of granules and their biochemical behavior was tested by in vivo studies: (i) composite materials consisting of gelatin and bi-phase ion modified calcium phosphate Mg, Zn-(HA + beta-TCP); and (ii) ceramics of ion modified calcium phosphate Mg, Zn-(HA + beta-TCP). The starting fine powders were prepared by the method of biomimetic precipitation of the precursors followed by high-temperature treatment. Then granules were prepared by dispersion in liquid paraffin of a thick suspension containing 20% of gelatin gel and thus prepared calcium phosphate powders (1: 1 ratios). The composite granules were obtained by subsequent hardening in a glutaraldehyde solution, while the highly porous ceramic granules - by further sintering at 1100 degrees C. The in vivo behavior of both types of granules was tested in experimental rat models. Bone defects were created in rat tibia and were filled with the implants. Biochemical studies were performed. Three months after operation both bio-materials displayed analogous behavior.
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