4.6 Article

Proteogenomic Analysis of Surgically Resected Lung Adenocarcinoma

Journal

JOURNAL OF THORACIC ONCOLOGY
Volume 13, Issue 10, Pages 1519-1529

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jtho.2018.06.025

Keywords

Lung adenocarcinoma; NSCLC; Biomarkers; Proteomics; Proteogenomics

Funding

  1. Vanderbilt lung cancer NCI SPORE grant [CA090949]
  2. National Library of Medicine Fellowship [4T15LM011270]

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Introduction: Despite apparently complete surgical resection, approximately half of resected early-stage lung cancer patients relapse and die of their disease. Adjuvant chemotherapy reduces this risk by only 5% to 8%. Thus, there is a need for better identifying who benefits from adjuvant therapy, the drivers of relapse, and novel targets in this setting. Methods: RNA sequencing and liquid chromatography/liquid chromatography-mass spectrometry proteomics data were generated from 51 surgically resected non-small cell lung tumors with known recurrence status. Results: We present a rationale and framework for the incorporation of high-content RNA and protein measurements into integrative biomarkers and show the potential of this approach for predicting risk of recurrence in a group of lung adenocarcinomas. In addition, we characterize the relationship between mRNA and protein measurements in lung adenocarcinoma and show that it is outcome specific. Conclusions: Our results suggest that mRNA and protein data possess independent biological and clinical importance, which can be leveraged to create higher-powered expression biomarkers. (C) 2018 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

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